Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: differing mechanisms of susceptibility and protection

Cutting Edge: The Conversion of Arginine to Citrulline Allows for a High-Affinity Peptide Interaction with the Rheumatoid Arthritis-Associated HLA-DRB1*0401 MHC Class II Molecule

Jonathan A. Hill, Scott Southwood, Alessandro Sette et al. · The Journal of Immunology · 2003 · 707 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA–DRB1 shared epitope for antibodies to citrullinated proteins

T. Huizinga, Christopher I. Amos, Annette H M van der Helm–van Mil et al. · Arthritis & Rheumatism · 2005 · 589 citations

Life Sciences, Clinical Sciences, Immunology +17

The HLA–DRB1 shared epitope alleles are primarily a risk factor for anti–cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis

Annette H M van der Helm–van Mil, K. N. Verpoort, Ferdinand C. Breedveld et al. · Arthritis & Rheumatism · 2006 · 349 citations

Life Sciences, Immunology, Internal Medicine +15

Regulation of anti–cyclic citrullinated peptide antibodies in rheumatoid arthritis: Contrasting effects of HLA–DR3 and the shared epitope alleles

Patricia Irigoyen, Annette T. Lee, Mark H. Wener et al. · Arthritis & Rheumatism · 2005 · 212 citations

Life Sciences, Immunology, Internal Medicine +17

New classification of HLA–DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility

Sophie Tézenas du Montcel, Laëtitia Michou, Élisabeth Petit et al. · Arthritis & Rheumatism · 2005 · 193 citations

Life Sciences, Genetics, Immunology +17