The design of optimal therapeutic small interfering RNA molecules targeting diverse strains of influenza A virus

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.3K citations

Natural Sciences, Rna Splicing, Rna Biology +9

Rational siRNA design for RNA interference

Angela Reynolds, Devin Leake, Queta Boese et al. · Nature Biotechnology · 2004 · 2.1K citations

Rational Sirna Design, Natural Sciences, Rna Biology +7

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

Jianhua Sui, W.C. Hwang, Sandra Pérez et al. · Nature Structural & Molecular Biology · 2009 · 1.1K citations · Full text

Virus Structure, Broad-spectrum Neutralization, Human Influenza +5

Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity

Aimee L. Jackson, Julja Burchard, Janell M. Schelter et al. · RNA · 2006 · 954 citations · Full text

Engineering, Genetics, Sirna Seed Region +17

3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets

Amanda Birmingham, Emily M. Anderson, Angela Reynolds et al. · Nature Methods · 2006 · 880 citations

Transcriptional Regulation, Functional Genomics, Natural Sciences +14