Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

Julian Downward, Yosef Yarden, E. L. V. Mayes et al. · Nature · 1984 · 2.5K citations · Full text

Medicine, Genetics, Molecular Biology +10

Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival

Jennifer R. Grandis, Mona F. Melhem, William E. Gooding et al. · JNCI Journal of the National Cancer Institute · 1998 · 1.1K citations · Full text

Medicine, Oncology, Pathology +17

Phase I and Pharmacologic Study of OSI-774, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced Solid Malignancies

Manuel Hidalgo, Lillian L. Siu, John Nemunaitis et al. · Journal of Clinical Oncology · 2001 · 1K citations

Medicine, Oncology, Pharmacology +15

A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.

Fortunato Ciardiello, Giampaolo Tortora · PubMed · 2001 · 988 citations

Medicine, Oncology, Pharmacology +17

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

Albert J. Wong, J. Michael Ruppert, Sandra H. Bigner et al. · Proceedings of the National Academy of Sciences · 1992 · 858 citations

Medicine, Genetics, Oncology +6