Concepedia

Characterization of Functional Excision Repair Cross-Complementation Group 1 Variants and Their Association with Lung Cancer Risk and Prognosis

Dianke Yu, Xuemei Zhang, Ju Liu, Peng Yuan, Wen Tan, Yongli Guo, Tong Sun, Dan Zhao, Ming Yang, Junniao Liu,

Clinical Cancer Research · 2008 · 76 citations · 36 references

DOIFull text

Open access

Abstract

These findings are consistent with the notion that DNA repair is a double-edged sword in cancer and suggest that functional single-nucleotide polymorphisms in ERCC1 might serve as simple and less invasive biomarkers for personalized chemotherapy of platinum-based anticancer drugs.

References

36

Haploview: analysis and visualization of LD and haplotype maps

Jeffrey C. Barrett, Ben Fry, Julian Maller et al. · Bioinformatics · 2004 · 14.5K citations · Full text

Score Tests for Association between Traits and Haplotypes when Linkage Phase Is Ambiguous

Daniel J. Schaid, Charles M. Rowland, David E. Tines et al. · The American Journal of Human Genetics · 2002 · 1.8K citations · Full text

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DNA Repair by ERCC1 in Non–Small-Cell Lung Cancer and Cisplatin-Based Adjuvant Chemotherapy

Ken A. Olaussen, Ariane Dunant, Pierre Fouret et al. · New England Journal of Medicine · 2006 · 1.7K citations · Full text

Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer.

Reginald V. Lord, Jan Brabender, David R. Gandara et al. · PubMed · 2002 · 671 citations

Cisplatin and Etoposide Regimen Is Superior to Cyclophosphamide, Epirubicin, and Vincristine Regimen in Small-Cell Lung Cancer: Results From a Randomized Phase III Trial With 5 Years’ Follow-Up

Stein Sundstrøm, Roy M. Bremnes, Stein Kaasa et al. · Journal of Clinical Oncology · 2002 · 501 citations