Chemical Communications · 2014 · 129 citations · 31 references
PharmacyBiomedical EngineeringPharmaceuticsDrug DeliveryNanoparticle Drug DeliveryStimuli-responsive Drug DeliveryControlled Release MechanismsDrug EncapsulationNanomaterials For Drug DeliveryNanomedicineNanoparticle Delivery SystemsNanoparticle DesignDrug Delivery NanocarriersExcitationMultifunctional NanoparticlesNanocarriersNanoparticle-based Controlled ReleasePolymer NanocarriersSolubilityUpconversion Nanoparticles
A water-soluble nanocarrier for a photo-activated CO releasing moiety (photoCORM) that can be triggered with NIR excitation is described. This has an upconversion nanoparticle core encapsulated by an amphiphilic polymer imparting both water solubility and a hydrophobic interior containing the photoCORM trans-Mn(bpy)(PPh3)2(CO)2. Such an ensemble offers a unique strategy for CO delivery to biological targets.
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Markus Haase, Helmut Schäfer · Angewandte Chemie International Edition · 2011 · 2.5K citations