Concepedia

Protective Effect of a Tuberculosis Subunit Vaccine Based on a Fusion of Antigen 85B and ESAT-6 in the Aerosol Guinea Pig Model

Anja Weinreich Olsen, Ann Williams, Limei Meng Okkels, Graham Hatch, Peter Andersen

Infection and Immunity · 2004 · 193 citations · 13 references

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Concepts

Abstract

A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.

References

13

The Efficacy of Bacillus Calmette-Guerin Vaccination of Newborns and Infants in the Prevention of Tuberculosis: Meta-Analyses of the Published Literature

Graham A. Colditz, Catherine S. Berkey, Frederick Mosteller et al. · PEDIATRICS · 1995 · 692 citations

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Failure of the<i>Mycobacterium bovis</i>BCG Vaccine: Some Species of Environmental Mycobacteria Block Multiplication of BCG and Induction of Protective Immunity to Tuberculosis

Lise Brandt, Joana Feino Cunha, Anja Weinreich Olsen et al. · Infection and Immunity · 2002 · 455 citations

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Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis.

Marcus A. Horwitz, B W Lee, Barbara Jane Dillon et al. · Proceedings of the National Academy of Sciences · 1995 · 435 citations · Full text

, , +17

Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins

Peter Andersen · Infection and Immunity · 1994 · 422 citations · Full text

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The efficacy of bacillus Calmette-Guérin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature.

Graham A. Colditz, Catherine S. Berkey, Timothy F. Brewer et al. · PubMed · 1995 · 354 citations

, , +17