Publication | Open Access
Protective Effect of a Tuberculosis Subunit Vaccine Based on a Fusion of Antigen 85B and ESAT-6 in the Aerosol Guinea Pig Model
193
Citations
13
References
2004
Year
Microbial PathogensTuberculosis PreventionImmunologyImmunodominanceAntigen ProcessingInnate ImmunityImmune SystemAntigen 85BVaccine TargetMycobacterium TuberculosisFusion ProteinTuberculosis DiagnosticsTuberculosis Subunit VaccineProtective EffectVaccinologyPulmonary TuberculosisVaccine DevelopmentTuberculosisHumoral ImmunityClinical MicrobiologyVaccinationVaccine DesignMedicineViral Immunity
ABSTRACT A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.
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