Publication | Closed Access
Engineering A Uranyl‐Specific Binding Protein from NikR
80
Citations
28
References
2009
Year
Uranyl‐specific Binding ProteinBiochemistryProtein AssemblyProtein FoldingNatural SciencesStructural BioinformaticsDna ReplicationMolecular BiologyProtein EngineeringE. Coli NickelProtein NikrDna ComputingMedicineMulti-protein AssemblyNew Pick-up LineStructural BiologyBiomolecular Engineering
A new pick-up line: The first uranyl-selective DNA-binding protein is designed using the E. coli nickel(II)-responsive protein NikR as the template. The resulting NikR' protein binds uranyl (see picture) with a dissociation constant K(d) = 53 nM and selectively binds to DNA in the presence of uranyl.
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