PubMed · 1995 · 155 citations · 0 references
Life SciencesCell BiologyMolecular BiologyCancer GeneticsCarcinogenesisMolecular OncologyCancer Cell SignalingCell Cycle ControlCell Cycle SignalingCyclin-dependent KinasesTumor Suppressor GenesCyclin D RegulationCyclin RegulationP53-mediated ArrestP53-mediated Cell Cycle ArrestP53-mediated Cell Cycle RegulationP53-mediated Cell-cycle ArrestRetinoblastoma Family ProteinsTumor Suppressor P53
Cells induced to accumulate the p53 tumor suppressor protein have been shown to arrest in G1. This arrest is characterized by accumulation of the cyclin-dependent kinase inhibitor p21 (WAF1/CIP1) and of under-phosphorylated forms of retinoblastoma protein. We show here that accumulation of the wild-type p53 protein in either human or murine cells markedly increases expression of cyclin D1. The induction of cyclin D1 can also be mediated by a target of p53, the p21 (WAF1/CIP1) inhibitor of cyclin-dependent kinases. The relationship between the induction of cyclin D1 and G1 arrest defines a new cellular response to p53.