Concepedia

Relationship between Antiapoptotic Molecules and Metastatic Potency and the Involvement of DNA-Dependent Protein Kinase in the Chemosensitization of Metastatic Human Cancer Cells by Epidermal Growth Factor Receptor Blockade

Jee Hyun Um, Joong Keun Kwon, Chi-Dug Kang, Mi Ju Kim, Dong Sik Ju, Jae Ho Bae, Dong Wan Kim, Byung Seon Chung, Sun Hee Kim

Journal of Pharmacology and Experimental Therapeutics · 2004 · 41 citations · 24 references

DOI

Concepts

References

24

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.

Fortunato Ciardiello, R. Caputo, Roberto Bianco et al. · PubMed · 2000 · 938 citations

, , +17

Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.

Francis M. Sirotnak, Maureen F. Zakowski, V.A. Miller et al. · PubMed · 2000 · 762 citations

, , +15

Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck.

S. Huang, Jonathan M. Bock, Paul M. Harari · PubMed · 1999 · 718 citations

, , +17

Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.

Christiane J. Bruns, Carmen C. Solórzano, Matthew T. Harbison et al. · PubMed · 2000 · 501 citations

, , +17

Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.

Jan Brabender, Kathleen D. Danenberg, Ralf Metzger et al. · PubMed · 2001 · 457 citations

, , +16