Alkynylation of carbonyl compounds with terminal acetylenes promoted by ZnCl2 and Et3N: simple, mild and efficient preparation of propargylic alcohols

Organocerium reagents. Nucleophilic addition to easily enolizable ketones

Tsuneo Imamoto, Yasushi Sugiura, Nobuyuki Takiyama · Tetrahedron Letters · 1984 · 268 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Catalytic in Situ Generation of Zn(II)-Alkynilides under Mild Conditions:  A Novel CN Addition Process Utilizing Terminal Acetylenes

Doug E. Frantz, Roger Fässler, Erick M. Carreira · Journal of the American Chemical Society · 1999 · 229 citations

Natural Sciences, Chemical Engineering, Chemistry +13

A Novel, Highly Enantioselective Ketone Alkynylation Reaction Mediated by Chiral Zinc Aminoalkoxides

Lushi Tan, Cheng‐Yi Chen, Richard D. Tillyer et al. · Angewandte Chemie International Edition · 1999 · 185 citations

Pharmacy, Chemistry, Medicinal Chemistry +13

Lithium Ephedrate-Mediated Addition of a Lithium Acetylide to a Ketone:  Solution Structures and Relative Reactivities of Mixed Aggregates Underlying the High Enantioselectivities

Andrew S. Thompson, Edward G. Corley, Martha Huntington et al. · Journal of the American Chemical Society · 1998 · 162 citations

Natural Sciences, Chemistry, Catalysis +10

Synthetic studies on (2R,4'R,8'R)-.alpha.-tocopherol. Facile syntheses of optically active, saturated, acyclic isoprenoids via stereospecific [3,3] sigmatropic rearrangements

Ka-Kong Chan, Noal Cohen, James P. De Noble et al. · The Journal of Organic Chemistry · 1976 · 157 citations

Natural Sciences, Chemistry, Bioisosterism +7