American Journal of Medical Genetics Part B Neuropsychiatric Genetics · 2009 · 22 citations · 15 references
Life SciencesGeneticsMolecular GeneticsGenetic EpidemiologyHuman GeneticsMedical GeneticsAnorexia NervosaDisease Susceptibility LociGenetic SusceptibilityGenome-wide Association StudiesGenotype-phenotype Association AnalysisPsychiatric GeneticsGenetic Association AnalysisGenetic Risk VariantsGenome-wide Association MappingGenome-wide Association Study DesignGenotype-phenotype AssociationsLogistic Regression
The influence of body mass index (BMI) on susceptibility to anorexia nervosa (AN) is not clear. Recently published genome-wide association (GWA) studies of the general population identified several variants influencing BMI. We genotyped these variants in an AN sample to test for association and to investigate a combined effect of BMI-increasing alleles (as determined in the original GWA studies) on the risk of developing the disease. Individual single nucleotide polymorphisms (SNPs) were tested for association with AN in a sample of 267 AN patients and 1,636 population controls. A logistic regression for the combined effect of BMI-increasing alleles included 225 cases and 1,351 controls. We found no significant association between individual SNPs and AN. The analysis of a combined effect of BMI-increasing alleles showed absence of association with the investigated condition. The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN.
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