Tethered spheroids as an in vitro hepatocyte model for drug safety screening

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 181.5K citations

Life Sciences, Molecular Biology, Molecular Genetics +9

A Threshold Selection Method from Gray-Level Histograms

Nobuyuki Otsu · IEEE Transactions on Systems Man and Cybernetics · 1979 · 43.1K citations

Computing, Computer Science, Computer Vision +12

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

Avri Ben‐Ze'ev, Greg Robinson, Nancy L. R. Bucher et al. · Proceedings of the National Academy of Sciences · 1988 · 533 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities.

Jacques Landry, Denis Bernier, Catherine Ouellet et al. · The Journal of Cell Biology · 1985 · 521 citations · Full text

Medicine, Biomedical Sciences, Cell Biology +17