Concepedia

Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death

Julien Verrax, Julie Cadrobbi, Carole Marques, Henryk Taper, Yvette Habraken, Jacques Piette, Pedro Buc Calderón

APOPTOSIS · 2004 · 105 citations · 47 references

Concepts

Life SciencesOncologyPharmacologyApoptosisCancer PharmacologyApoptosis In CancerApoptosis ModulationApoptosis PharmacologyApoptosis RegulationApoptotic SignalingReactive Oxygen SpeciesCaspase SignalingCaspase-independent ApoptosisOxidative Stress - Induced ApoptosisOxidative Stress In CancerOxidative Stress InjuryOxidative Stress-induced ApoptosisOxidative Stress-induced Cell DeathRedox Control Of Cell Death

References

47

Superoxide Dismutase

Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry · 1969 · 12.8K citations · Full text

Life Sciences, Biochemistry, Enzymology +11

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

A H Wyllie · Nature · 1980 · 4.5K citations

Life Sciences, Cell Biology, Molecular Biology +14

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.

Ralf Schreck, P. Rieber, Patrick A. Baeuerle · The EMBO Journal · 1991 · 3.8K citations · Full text

Life Sciences, Immunology, Molecular Biology +11

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

David M. Hockenbery, Zoltán N. Oltvai, Xiao-Ming Yin et al. · Cell · 1993 · 3.4K citations

Life Sciences, Biochemistry, Cell Biology +12

[44] Glutathione peroxidase

Albrecht Wendel · Methods in enzymology on CD-ROM/Methods in enzymology · 1981 · 3K citations