Fibrogenic Polymorphisms (TGF-β, PAI-1, AT) in Mexican Patients with Established Liver Fibrosis. Potential Correlation with Pirfenidone Treatment

Abstract

Our data suggested that a combination of inherited polymorphisms increased the risk of advanced fibrosis in ELF patients. Pure HCV and pure alcohol consumption patients which were homozygous G/G carriers had 19.5- and 10.8-fold higher risk to develop advanced fibrosis respectively.