Rifaximin Is a Gut-Specific Human Pregnane X Receptor Activator

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

Steven A. Kliewer, Kazuhiko Umesono, Daniel J. Noonan et al. · Nature · 1992 · 1.7K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Jeff L. Staudinger, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2001 · 1.4K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +13

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

Heidi R. Kast-Woelbern, Bryan Goodwin, Paul T. Tarr et al. · Journal of Biological Chemistry · 2002 · 908 citations · Full text

Medicine, Molecular Biology, Pharmacology +17

Identification of a human nuclear receptor defines a new signaling pathway for <i>CYP</i> <i>3</i> A induction

Göran Bertilsson, Jessica Heidrich, Kristian Svensson et al. · Proceedings of the National Academy of Sciences · 1998 · 871 citations · Full text

Medicine, Molecular Biology, Pharmacology +15

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice†

Martin Wagner, Emina Halilbasic, Hanns–Ulrich Marschall et al. · Hepatology · 2005 · 346 citations · Full text

Medicine, Pharmacology, Toxicology +17