Concepedia

Boosting of HIV Protease Inhibitors by Ritonavir in the Intestine: The Relative Role of Cytochrome P450 and P-Glycoprotein Inhibition Based on Caco-2 Monolayers versus In Situ Intestinal Perfusion in Mice

Nico Holmstock, Pieter Annaert, Patrick Augustijns

Drug Metabolism and Disposition · 2012 · 55 citations · 15 references

DOI

Concepts

References

15

Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors

Yasuo Uchida, Sumio Ohtsuki, Yuki Katsukura et al. · Journal of Neurochemistry · 2011 · 909 citations

, , +15

Identification of Novel Specific and General Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 Among Registered Drugs

Pär Matsson, Jenny M. Pedersen, Ulf Norinder et al. · Pharmaceutical Research · 2009 · 313 citations

, , +13

Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir

Irina F. Sevrioukova, T.L. Poulos · Proceedings of the National Academy of Sciences · 2010 · 286 citations · Full text

, , +17

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Rose Hayeshi, Constanze Hilgendorf, Per Artursson et al. · European Journal of Pharmaceutical Sciences · 2008 · 264 citations

, , +14

Dissolution media simulating the intralumenal composition of the small intestine: physiological issues and practical aspects

Maria Vertzoni, Nikoletta Fotaki, Eleftheria Nicolaides et al. · Journal of Pharmacy and Pharmacology · 2004 · 236 citations · Full text

, , +17