<i>BRCA1</i> and<i>BRCA2</i> mutation status and cancer family history of Danish women affected with multifocal or bilateral breast cancer at a young age

Abstract

A relatively broad spectrum of germline mutations was observed in BRCA1 and BRCA2 and most of the mutations are present in other populations. Our results indicate that a diagnosis of bilateral and multifocal breast cancer is predictive of BRCA1 and BRCA2 mutation status, particularly when combined with information on the patients' age at diagnosis and family history of breast/ovarian cancer.