Risk for myasthenia gravis maps to a ¹⁵¹ Pro→Ala change in TNIP1 and to human leukocyte antigen‐B*08

Abstract

The association at TNIP1 in EOMG implies disease mechanisms involving ubiquitin-dependent dysregulation of NF-κB signaling. The localization of the major HLA signal to the HLA-B*08 allele suggests that CD8(+) T cells may play a key role in disease initiation or pathogenesis.