Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

The Lancet · 1998 · 8.3K citations

Medicine, Endocrinology, Pharmacotherapy +17

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.4K citations

Life Sciences, Endocrinology, Pharmacology +16

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Takeshi Nishikawa, Diane Edelstein, Xue Du et al. · Nature · 2000 · 4.3K citations

Life Sciences, Biochemistry, Physiology +14

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

Toyoshi Inoguchi, Pan Li, F. Umeda et al. · Diabetes · 2000 · 1.6K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

S D Yan, Ann Marie Schmidt, Geoffrey M. Anderson et al. · Journal of Biological Chemistry · 1994 · 1.3K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17