High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

Toyoshi Inoguchi, Pan Li, F. Umeda, +10

Diabetes

Lipid PeroxidationReactive Oxygen SpeciesRedox BiologyOxidative StressMetabolic Syndrome +19

Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes

Tetsuro Sano, F. Umeda, T. Hashimoto, +2

Diabetologia

Reductive StressMetabolic SyndromeBiochemistryMagnetic Resonance SpectroscopyLipid Peroxidation +10

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

Makoto Kunisaki, Sven–Erik Bursell, Allen C. Clermont, +6

American Journal of Physiology-Endocrinology and Metabolism

High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells.

Tatsuya Kuroki, Toyoshi Inoguchi, F. Umeda, +2

Diabetes

Gap JunctionCytoskeletonCell JunctionsCellular PhysiologySignaling Pathway +18

Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells

T. Yamauchi, F. Umeda, Mitsunori Masakado, +3

Biochemical Journal

ImmunologyCell ProliferationCytoskeletonProstacyclin-stimulating FactorCellular Physiology +20

Effects of a New Oral Hypoglycaemic Agent (CS‐045) on Metabolic Abnormalities and Insulin Resistance in Type 2 Diabetes

Kazuo Mimura, F. Umeda, S. Hiramatsu, +7

Diabetic Medicine

Insulin SignalingObesityMetabolic SyndromeOral Cs-045Health Sciences +15

Effects of free fatty acids on β-cell functions: A possible involvement of peroxisome proliferator-activated receptors α or pancreatic/duodenal homeobox

Hiroyasu YOSHIKAWA, Yuji Tajiri, Y. Sako, +3

Metabolism

InflammationMetabolic SyndromeBiochemistryLiver PhysiologyPhysiology +8

High incidence of silent myocardial ischemia in elderly patients with non insulin-dependent diabetes mellitus

Toyoshi Inoguchi, Tomoya Yamashita, F. Umeda, +7

Diabetes Research and Clinical Practice

Metabolic SyndromeSilent Myocardial IschemiaCardiovascular DiseaseHealth PolicyAtherosclerosis +10

Effect of Vitamin E on Platelet Aggregation in Diabetes Mellitus

Jun Watanabe, F. Umeda, Hideyuki Wakasugi, +1

Thrombosis and Haemostasis

NutritionPlatelet AggregationMetabolic SyndromeThrombosisHematology +16

Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells

Toyoshi Inoguchi, Maiko Kakimoto, Naoki Nakashima, +4

Diabetologia

BiochemistryDiacylglycerol SynthesisPhysiologyVascular BiologyLipoprotein Metabolism +6