Toyoshi Inoguchi

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

Toyoshi Inoguchi, Pan Li, F. Umeda et al. · Diabetes · 2000 · 1.6K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

Toyoshi Inoguchi, Ruggero Battan, Eugene S. Handler et al. · Proceedings of the National Academy of Sciences · 1992 · 740 citations

Life Sciences, Biochemistry, Endocrinology +14

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

Pu Xia, Toyoshi Inoguchi, Timothy S. Kern et al. · Diabetes · 1994 · 456 citations

Life Sciences, Biochemistry, Endocrinology +14

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

Teruo Shiba, Toyoshi Inoguchi, J. Richard Sportsman et al. · American Journal of Physiology-Endocrinology and Metabolism · 1993 · 317 citations

Life Sciences, Biochemistry, Ophthalmology +9

ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts

Minako Imamura, Toyoshi Inoguchi, Shoichiro Ikuyama et al. · American Journal of Physiology-Endocrinology and Metabolism · 2002 · 279 citations

Life Sciences, Cell Biology, Molecular Biology +17