Functional Analysis of the TRIB <i>1</i> Associated Locus Linked to Plasma Triglycerides and Coronary Artery Disease

Abstract

These studies demonstrate an interplay between a novel locus, TRIBAL, and TRIB1. TRIBAL is located in the genome-wide association studies identified risk locus, responds to altered expression of TRIB1, harbors a risk SNP that is an eQTL for TRIB1 expression, and associates with plasma triglyceride concentrations.