Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of dibenzofluorene derivatives

Polycyclic aromatic hydrocarbons; chemistry and carcinogenicity

General Pharmacology The Vascular System · 1992 · 542 citations

Pharmacy, Chemistry, Toxicology +12

Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of minimal DNA-intercalating agents which may not act via topoisomerase II

William A. Denny, Gordon W. Rewcastle, Bruce C. Baguley · Journal of Medicinal Chemistry · 1990 · 309 citations

Medicine, Medicinal Chemistry, Pharmacology +12

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

Dhiren R. Thakker, Haruhiko Yagi, Anthony Y.H. Lu et al. · Proceedings of the National Academy of Sciences · 1976 · 205 citations · Full text

Life Sciences, Biochemistry, Toxicology +15

A new general synthesis of polycyclic aromatic compounds based on enamine chemistry

Ronald G. Harvey, J. Pataki, Cecilia Cortez et al. · The Journal of Organic Chemistry · 1991 · 116 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides

Brian D. Palmer, Gordon W. Rewcastle, Graham J. Atwell et al. · Journal of Medicinal Chemistry · 1988 · 84 citations

Medicine, Medicinal Chemistry, Pharmacology +7