Pioglitazone improves insulin secretory capacity and prevents the loss of β-cell mass in obese diabetic db/db mice: possible protection of β cells from oxidative stress

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

David R. Matthews, J P Hosker, A. Rudenski et al. · Diabetologia · 1985 · 31.4K citations · Full text

Medicine, Endocrinology, Physiology +17

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Jürgen M. Lehmann, Linda B. Moore, Tracey Smith-Oliver et al. · Journal of Biological Chemistry · 1995 · 3.6K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

Norikazu Maeda, Masahiko Takahashi, Tohru Funahashi et al. · Diabetes · 2001 · 1.7K citations · Full text

Medicine, Endocrinology, Pharmacology +14

Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians

Stephen Lillioja, David M. Mott, Maximilian Spraul et al. · New England Journal of Medicine · 1993 · 1.5K citations · Full text

Medicine, Endocrinology, Diabetology +14

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

Blaise C. Martin, James H. Warram, Andrzej S. Królewski et al. · The Lancet · 1992 · 1.2K citations

Medicine, Endocrinology, Diabetology +11