Whole-Genome Sequencing for National Surveillance of Shiga Toxin–Producing<i>Escherichia coli</i>O157

Abstract

WGS has come of age as a molecular typing tool to inform national surveillance of STEC O157; it can be used in real time to provide the highest strain-level resolution for outbreak investigation. WGS allows linked cases to be identified with unprecedented specificity and sensitivity that will facilitate targeted and appropriate public health investigations.