Concepedia

T-Cell Immunophenotyping Distinguishes Active From Latent Tuberculosis

Katrina M. Pollock, Hilary Whitworth, Damien Montamat‐Sicotte, Lisa Grass, Graham Cooke, Moses Kapembwa, Onn Min Kon, Robert D. Sampson, Graham P. Taylor, Ajit Lalvani

The Journal of Infectious Diseases · 2013 · 104 citations · 31 references

DOIFull text

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Abstract

Combined measurement of T-cell phenotype and function defines a highly discriminatory biomarker of tuberculosis disease activity. Unlocking the diagnostic and monitoring potential of this combined approach now requires validation in large-scale prospective studies.

References

31

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Mice Deficient in CD4 T Cells Have Only Transiently Diminished Levels of IFN-γ, Yet Succumb to Tuberculosis

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