Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

Life Sciences, Cell Biology, Apoptosis +14

Human Malaria Parasites in Continuous Culture

William Trager, James B. Jensen · Science · 1976 · 8K citations

Life Sciences, Biology, Infectious Diseases +15

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

R. E. Desjardins, Craig J. Canfield, J. David Haynes et al. · Antimicrobial Agents and Chemotherapy · 1979 · 2.5K citations · Full text

Medicine, Infectious Diseases, Pharmacology +17

Efflux of Chloroquine from <i>Plasmodium falciparum</i> : Mechanism of Chloroquine Resistance

Donald J. Krogstad, Ilya Y. Gluzman, Dennis E. Kyle et al. · Science · 1987 · 523 citations

Medicine, Pharmacokinetics, Pharmacology +17

Structure−Function Relationships in Aminoquinolines:  Effect of Amino and Chloro Groups on Quinoline−Hematin Complex Formation, Inhibition of β-Hematin Formation, and Antiplasmodial Activity

Timothy J. Egan, Roger Hunter, Catherine H. Kaschula et al. · Journal of Medicinal Chemistry · 1999 · 311 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10