Effects of oral glucosamine sulphate on serum glucose and insulin during an oral glucose tolerance test of subjects with osteoarthritis

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

Stephen Marshall, V. Bacote, R.R. Traxinger · Journal of Biological Chemistry · 1991 · 1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

Leon F. Hebert, Marc C. Daniels, Errol D. Crook et al. · Journal of Clinical Investigation · 1996 · 334 citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.

Luciano Rossetti, Meredith Hawkins, Wanghua Chen et al. · Journal of Clinical Investigation · 1995 · 264 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.

Mary‐Elizabeth Patti, A Virkamäki, Edwin J. Landaker et al. · Diabetes · 1999 · 253 citations

Life Sciences, Biochemistry, Endocrinology +17

Pre-Exposure to Glucosamine Induces Insulin Resistance of Glucose Transport and Glycogen Synthesis in Isolated Rat Skeletal Muscles: Study of Mechanisms in Muscle and in Rat-1 Fibroblasts Overexpressing the Human Insulin Receptor

Kathrine A Robinson, Donald A. Sens, Maria G. Buse · Diabetes · 1993 · 161 citations

Life Sciences, Biochemistry, Endocrinology +17