Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1α in acinar cell homeostasis

Abstract

Dynamic changes in gene expression occur on pancreatitis induction, determining altered exocrine and endocrine function. This analysis uncovers roles for Hnf1α in the regulation of acinar cell determination and function. This effect may be mediated, in part, through direct regulation of Nr5a2.