Conjugation of Desmethylnaproxen in the Rat—A Novel Acyl Glucuronide-Sulfate Diconjugate as a Major Biliary Metabolite

Physiological disposition and metabolism of 5-(2',4'-difluorophenyl)salicyclic acid, a new salicylate.

Dominick J. Tocco, G. O. Breault, Anthony G. Zacchei et al. · PubMed · 1976 · 83 citations

Pharmacy, Pharmacokinetics, Pharmacology +9

Evidence for the Intraluminal Positioning of p-Nitrophenol UDP-glucuronosyltransferase Activity in Rat Liver Microsomal Vesicles

Rosella Fulceri, Gábor Bánhegyi, Alessandra Gamberucci et al. · Archives of Biochemistry and Biophysics · 1994 · 81 citations

Pharmacy, Biochemistry, Molecular Biology +16

Bioactivation of a Toxic Metabolite of Valproic Acid, (<i>E</i>)-2-Propyl-2,4-pentadienoic Acid, via Glucuronidation. LC/MS/MS Characterization of the GSH−Glucuronide Diconjugates

Wei Tang, Frank S. Abbott · Chemical Research in Toxicology · 1996 · 48 citations

Medicine, Pharmacology, Toxicology +14

Pharmacokinetics of naproxen, its metabolite <i>O</i>‐desmethylnaproxen, and their acyl glucuronides in humans

Tom B. Vree, M. van den Biggelaar-Martea, C.P.W.G.M. Verwey-van Wissen et al. · Biopharmaceutics & Drug Disposition · 1993 · 46 citations

Medicine, Pharmacokinetics, Pharmacology +9

The pharmacokinetics of naproxen, its metabolite O‐desmethylnaproxen, and their acyl glucuronides in humans. Effect of cimetidine.

T. B. Vree, M. van den Biggelaar-Martea, CP Verwey‐Van Wissen et al. · British Journal of Clinical Pharmacology · 1993 · 46 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12