Concepedia

DISCORDANT NEURAL TISSUE XENOGRAFTS SURVIVE LONGER IN IMMUNOGLOBULIN DEFICIENT MICE1

Lena C. Larsson, Kimberly A. Czech, Håkan Widner, Olle Korsgren

Transplantation · 1999 · 58 citations · 48 references

DOI

Abstract

Our results suggest that immunoglobulins play an initiating role in rejection of discordant neural xenografts. After a prolonged graft survival of approximately 4 weeks, a cellular response with a large proportion CD8-positive cells leads to rejection in IgKO mice.

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