Publication | Closed Access
A Dynamic Kinetic Resolution of Allyl Alcohols by the Combined Use of Lipases and [VO(OSiPh<sub>3</sub>)<sub>3</sub>]
142
Citations
34
References
2006
Year
Bioorganic ChemistryEngineeringThermodynamic MixturesOrganic ChemistryChemistryCombined UseRacemic AllylBiochemical EngineeringStereoselective SynthesisMolecular KineticsAlcohol DehydrogenasesBiochemistryBiocatalysisNatural Product SynthesisAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringDynamic Kinetic ResolutionAllyl AlcoholsNatural SciencesEnzyme CatalysisLipid ChemistryChemical Kinetics
Mix and match: A new type of dynamic kinetic resolution of racemic allyl alcohols uses a combination of lipases and [VO(OSiPh3)3] (1). The 1,3-transposition of allyl alcohols catalyzed by 1 gave thermodynamic mixtures of two regioisomers, which underwent highly enantio- and chemoselective esterification with lipases. Optically enriched allyl acetates were isolated in high yields.
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