Expanding the Functional Group Compatibility of Small‐Molecule Microarrays: Discovery of Novel Calmodulin Ligands

Abstract

The importance of the pKa value: Phenols, carboxylic acids, and compounds containing comparably acidic functional groups are covalently captured on a diazobenzylidene-functionalized glass surface. This new covalent slide-capture method has been used to print 6336 diversity-oriented synthesis-derived phenol-containing fused bicycles and tetracycles, from which new calmodulin ligands were identified (see schematic representation). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51043_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.