Concepedia

Publication | Open Access

Protease-Activated Receptor-1 Contributes to Cardiac Remodeling and Hypertrophy

DOIFull Paper Access

142

Citations

25

References

2007

Year

Rafał Pawliński, Michael Tencati, Craig R. Hampton, Tetsuro Shishido, Tara A. Bullard, Liam M. Casey, Patricia Andrade‐Gordon, Matthias Kotzsch, Denise J. Spring, Thomas Luther,
Circulation

Abstract

Our results demonstrate that PAR-1 contributes to cardiac remodeling and hypertrophy. Moreover, overexpression of PAR-1 on cardiomyocytes induced eccentric hypertrophy. Inhibition of PAR-1 after myocardial infarction may represent a novel therapy to reduce hypertrophy and heart failure in humans.

References

YearCitations

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