Neurology · 1990 · 24 citations · 0 references
MedicineNephrologyPharmacologyDialysisHemodialysisRenal Replacement TherapyAcid-base ManagementDialysate CompositionDialysis PharmacotherapyHemodialysis ComplicationsPharmacokinetics In Renal ImpairmentRenal Drug ClearanceDrug Clearance By HemodialysisDrug Clearance During HemodialysisDrug Dosing During HemodialysisDrug Elimination Half-lifeHemodialysis PharmacokineticsMedication Clearance By HemodialysisSeizure PathophysiologyValproic Acid
We report a patient with dialysis-induced encephalopathy who was taking divalproex sodium for a seizure disorder. Her serum valproic acid concentration appeared to be in the low therapeutic range at 54 mg/l yet she continued to have seizure activity. The elimination half-life and apparent clearance of valproic acid were the same for both a dialysis and nondialysis day, indicating that hemodialysis/hemoperfusion has little effect on the overall removal of valproic acid from the body.