Concepedia

Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways

Si Gao, Tianfeng Chen, Mei-Yuk Choi, Yuanwei Liang, Junyi Xue, Yum-Shing Wong

Cancer Letters · 2013 · 73 citations · 33 references

Concepts

Life SciencesMolecular BiologyOncologyApoptosisChemotherapySignal TransductionApoptosis In CancerApoptosis RegulationApoptotic SignalingCytotoxic ChemotherapyDna Damage SignalingDna Damage-induced ApoptosisAkt Survival SignalingApoptosis Regulation By KinasesDna Damage Response InhibitorsDna Damage Response SignalingDna Damage-induced Cell DeathProximal Tubular Dysfunction

References

33

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell · 1997 · 7.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

Michael C. Wei, Wei‐Xing Zong, Emily H. Cheng et al. · Science · 2001 · 3.9K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids

Catherine Rice‐Evans, Nicholas J. Miller, Paul Bolwell et al. · Free Radical Research · 1995 · 2.2K citations

Agriculture, Botany, Plant Sciences +15

TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity

Ganesan Ramesh, William Reeves · Journal of Clinical Investigation · 2002 · 753 citations · Full text

Medicine, Pharmacology, Toxicology +17

TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity

Ganesan Ramesh, William Reeves · Journal of Clinical Investigation · 2002 · 701 citations · Full text

Medicine, Pharmacology, Toxicology +17