Areca nut alkaloids induce irreparable <scp>DNA</scp> damage and senescence in fibroblasts and may create a favourable environment for tumour progression

Abstract

Areca nut alkaloids induce senescence in oral fibroblasts and promote increased secretion of TGF-β and perhaps MMP-2 that may create a tissue environment thought to be critical in the progression of OSMF to malignancy.