Notoginsenoside R1 Attenuates Experimental Inflammatory Bowel Disease via Pregnane X Receptor Activation

Mutual repression between steroid and xenobiotic receptor and NF- B signaling pathways links xenobiotic metabolism and inflammation

Changcheng Zhou · Journal of Clinical Investigation · 2006 · 376 citations · Full text

Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes

Thomas Langmann, Christoph Moehle, Richard Mauerer et al. · Gastroenterology · 2004 · 330 citations · Full text

Inflammation, Autoimmune Disease, Mucosal Immunology +8

Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs

Carlo Patrono, Paola Patrignani, Luis A. Garcı́a Rodrı́guez · Journal of Clinical Investigation · 2001 · 304 citations

Heart Failure, Prognosis, Epidemiology Of Cancer +31

Role of NF-κB in Regulation of PXR-mediated Gene Expression

Xinsheng Gu, Sui Ke, Duan Liu et al. · Journal of Biological Chemistry · 2006 · 298 citations · Full text

Pxr-mediated Gene Expression, Immunology, Immune Regulation +20

Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression

Yatrik M. Shah, Xiaochao Ma, Keiichirou Morimura et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 2006 · 228 citations

Chronic Inflammatory Diseases, Pxr Agonist, Immune Regulation +18