Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs

Abstract

Table 1 Incidence rates of major events possibly prevented or caused by COX inhibitors, as assessed in observational studies among non-users Event Incidence rate per 1,000 patient-years Heart failure 2-4 Myocardial infarction 1-4 Upper GI bleeding/perforation 0.6-1.7 Colorectal cancer 0.4-0.7 Acute renal failure 0.02-0.08