Synthesis of Diacylated Trehalose Sulfates: Candidates for a Tuberculosis Vaccine

Abstract

Able antigen analogues: Analogues of the mycobacterial sulfoglycolipid antigen 1 isolated from Mycobacterium tuberculosis have been prepared by a short and general route. Some derivatives showed interesting immunogenic properties and activated cytotoxic T cells. Immunogenic analogues contained a chiral saturated or α,β-unsaturated polymethylated fatty acid with S configured stereogenic centers at the 3-position of the trehalose core. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.