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Novel reagent system for converting a hydroxy-group into an iodo-group in carbohydrates with inversion of configuration
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1979
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Novel OrganocatalystsEngineeringBiochemistryNatural SciencesBiocatalysisElevated TemperatureSecondary Hydroxy-groupsNovel Reagent SystemOrganic ChemistryDownstream ProcessingSynthetic ChemistryCarbohydrate-protein InteractionChemistryReagentHalogenationEfficient ConversionsBiomolecular Engineering
Efficient conversions of primary and secondary hydroxy-groups into iodo-groups, with inversion, in carbohydrates are described using either triphenylphosphine, iodine, and imidazole or triphenylphosphine and 2,4,5-tri-iodoimidazole in toluene at elevated temperature.