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Prostaglandin synthesis: design and execution
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1973
Year
Medicinal ChemistryNatural Product SynthesisProstaglandin SynthesisHeterocyclicDiversity Oriented SynthesisNatural SciencesDrug DiscoveryDiversity-oriented SynthesisMedicineRacemic Prostaglandin F2αOrganic ChemistryChemistryPharmacologySynthesis DesignSynthetic ChemistryBiomolecular EngineeringMany Possible Routes
Application of the principles of synthesis design to the problem of prostaglandins led to many possible routes, including one commencing with endo-dicyclopentadiene. This starting material was then converted into racemic prostaglandin F2α in a minimum often stages via bicyclo[3.3.0]octane intermediates.