Concepedia

Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock

Anand Kumar, Anand Kumar, Yaseen M. Arabi, Dan Roberts, Bruce Light, Joseph E. Parrillo, Peter Dodek, Gordon Wood, Aseem Kumar, Aseem Kumar,

CHEST Journal · 2009 · 1.2K citations · 41 references

Concepts

Veterinary MedicineInfectious DiseasesAntimicrobial PharmacotherapyAntimicrobial StewardshipSepsisAntibiotic ResistanceAntimicrobial TherapyEmpiric Antimicrobial TherapySepsis ManagementSepsis PathophysiologySeptic ShockAntimicrobial Therapy InterruptionSepsis Antimicrobial StewardshipSepsis Empiric TherapySeptic Shock Management

References

41

APACHE II

William A. Knaus, Elizabeth A. Draper, Douglas P. Wagner et al. · Critical Care Medicine · 1985 · 13.7K citations

Medicine, Internal Medicine, Clinical Classification Systems +16

APACHE II-A Severity of Disease Classification System

William A. Knaus, Elizabeth A. Draper, Douglas P. Wagner et al. · Critical Care Medicine · 1986 · 13.4K citations

Health Professions, Biostatistics, Clinical Classification Systems +12

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Gordon R. Bernard, Jean‐Louis Vincent, Pierre‐François Laterre et al. · New England Journal of Medicine · 2001 · 6.1K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +13

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

Anand Kumar, Daniel Roberts, Kenneth E. Wood et al. · Critical Care Medicine · 2006 · 6.1K citations

Veterinary Medicine, Infectious Diseases, Antimicrobial Pharmacotherapy +13

CDC definitions for nosocomial infections, 1988

Julia S. Garner, William R. Jarvis, T.Grace Emori et al. · American Journal of Infection Control · 1988 · 5.8K citations

Veterinary Medicine, Infectious Disease Control, Infectious Diseases +14