Joseph E. Parrillo

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

Anand Kumar, Daniel Roberts, Kenneth E. Wood et al. · Critical Care Medicine · 2006 · 6.1K citations

Veterinary Medicine, Infectious Diseases, Antimicrobial Pharmacotherapy +13

Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock

Anand Kumar, Anand Kumar, Yaseen M. Arabi et al. · CHEST Journal · 2009 · 1.2K citations

Veterinary Medicine, Infectious Diseases, Antimicrobial Pharmacotherapy +12

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

Anthony F. Suffredini, Robert E. Fromm, Margaret M. Parker et al. · New England Journal of Medicine · 1989 · 1.1K citations

Veterinary Medicine, Cardiology, Physiology +14

Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects

Anand Kumar, Ramon Añel, Eugene Bunnell et al. · Critical Care Medicine · 2004 · 813 citations

Medicine, Cardiology, Clinical Cardiology +15

Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum.

Aseem Kumar, V Thota, Linda Dee et al. · The Journal of Experimental Medicine · 1996 · 787 citations · Full text

Veterinary Medicine, Cardiology, Immunology +9