Joseph E. Parrillo

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

Anand Kumar, Daniel Roberts, Kenneth E. Wood et al. · Critical Care Medicine · 2006 · 5.9K citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

Anthony F. Suffredini, Robert E. Fromm, Margaret M. Parker et al. · New England Journal of Medicine · 1989 · 1.1K citations

Microbial Toxin, Hypertension, Heart Failure +15

Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects

Anand Kumar, Ramon Añel, Eugene Bunnell et al. · Critical Care Medicine · 2004 · 809 citations

Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum.

Aseem Kumar, V Thota, Linda Dee et al. · The Journal of Experimental Medicine · 1996 · 785 citations · Full text

Closed Loop Video, Cardiac Muscle, Immunology +16

A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.

Joseph E. Parrillo, Cynthia Burch, James H. Shelhamer et al. · Journal of Clinical Investigation · 1985 · 620 citations · Full text

Cardiac Muscle, Heart Failure, Reversible Depression +23