Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

Elizabeth A. Harrington, David Bebbington, Jeffrey R. Moore et al. · Nature Medicine · 2004 · 954 citations · Full text

Medicine, Oncology, Pharmacology +13

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

Debabrata Mukhopadhyay, Leonidas Tsiokas, Xiao-Mai Zhou et al. · Nature · 1995 · 597 citations

Life Sciences, Biochemistry, Cell Biology +14

SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

Robert A. Blake, Martin A. Broome, Xiangdong Liu et al. · Molecular and Cellular Biology · 2000 · 586 citations

Life Sciences, Molecular Biology, Cell Signaling +15

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

Hiroshi Katayama, Kaori Sasai, Hidehiko Kawai et al. · Nature Genetics · 2003 · 584 citations

Life Sciences, Cell Biology, Molecular Biology +14

MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

Francis J. Giles, Jörge E. Cortes, Dan Jones et al. · Blood · 2006 · 361 citations · Full text

Medicine, Oncology, Pharmacology +12