Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Napoleone Ferrara, Karen Carver-Moore, Helen Chen et al. · Nature · 1996 · 3.7K citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

Shay Söker, Seiji Takashima, Hua Miao et al. · Cell · 1998 · 2.5K citations · Full text

Medicine, Cancer Biology, Oncology +15

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

Dmitry I. Gabrilovich, Hailei L. Chen, Khaled R. Girgis et al. · Nature Medicine · 1996 · 2K citations

Life Sciences, Immunology, Oncology +13

A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases.

Vladimir Joukov, Katri Pajusola, Arja Kaipainen et al. · The EMBO Journal · 1996 · 1.7K citations · Full text

Life Sciences, Cell Biology, Pharmacology +11