Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase

MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry

Paul R. Gerber, Klaus M�ller · Journal of Computer-Aided Molecular Design · 1995 · 595 citations

Natural Sciences, Medicinal Chemistry, Biomolecular Modeling +15

dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae.

Michael H. Gadsden, Evan M. McIntosh, John C. Game et al. · The EMBO Journal · 1993 · 221 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +4

Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli

Hiyam H. El-Hajj, Henggui Zhang, B Weiss · Journal of Bacteriology · 1988 · 197 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

dUTPase as a Platform for Antimalarial Drug Design: Structural Basis for the Selectivity of a Class of Nucleoside Inhibitors

Jean L. Whittingham, Isabel Leal, Corinne Nguyen et al. · Structure · 2005 · 99 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Spermexatin and spermexatol: new synthetic spermidine-based siderophore analogs

Sushil K. Sharma, Marvin J. Miller, Shelley M. Payne · Journal of Medicinal Chemistry · 1989 · 78 citations

Pharmacy, Medicinal Chemistry, Pharmacology +6