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Myeloid‐Related Proteins 8 and 14 Contribute to Monosodium Urate Monohydrate Crystal–Induced Inflammation in Gout

DOI

69

Citations

46

References

2014

Year

Dirk Holzinger, Nadine Nippe, Thomas Vogl, Kristina Marketon, Vijayashree Mysore, Toni Weinhage, Nicola Dalbeth, Bregina Pool, Tony R. Merriman, Dominique Baeten,
Arthritis & Rheumatology

Abstract

MRP-8 and MRP-14, which are highly expressed in gout, are enhancers of MSU crystal-induced IL-1β secretion in vitro and in vivo. These endogenous TLR-4 ligands released by activated phagocytes contribute to the maintenance of inflammation in gout.

References

YearCitations

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