Concepedia

Rationally Designed Nucleoside Antibiotics That Inhibit Siderophore Biosynthesis of <i>Mycobacterium </i><i>t</i><i>uberculosis</i>

Ravindranadh V. Somu, Helena I. Boshoff, Chunhua Qiao, Eric M. Bennett, Clifton E. Barry, Courtney C. Aldrich

Journal of Medicinal Chemistry · 2005 · 235 citations · 20 references

DOI

Concepts

Abstract

A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC(99) = 0.19 microM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.

References

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