Concepedia

One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from In Situ Generated Azides

Alina K. Feldman, Benoît Colasson, Valery V. Fokin

Organic Letters · 2004 · 344 citations · 4 references

DOI

Concepts

Abstract

[reaction: see text] 1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields by a convenient one-pot procedure from a variety of readily available aromatic and aliphatic halides without isolation of potentially unstable organic azide intermediates.

References

4

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

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Peptidotriazoles on Solid Phase:  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides

Christian W. Tornøe, Caspar Christensen, Morten Meldal · The Journal of Organic Chemistry · 2002 · 8.5K citations

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Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

Qian Wang, Timothy R. Chan, Robert Hilgraf et al. · Journal of the American Chemical Society · 2003 · 1.6K citations

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Synthesis of aryl azides and vinyl azides via proline-promoted CuI-catalyzed coupling reactionsElectronic supplementary information (ESI) available: experimental procedures. See http://www.rsc.org/suppdata/cc/b4/b400878b/

Wei Zhu, Dawei Ma · Chemical Communications · 2004 · 279 citations

, , +10